CDMO Services
Tides
Drawing on Sanofi’s 15 years of experience in the field of oligonucleotides and 45 years in the field of peptides, EUROAPI provides a unique state-of-the-art platform for their development and scale-up at Hoechst Industrial Park in Frankfurt (Germany).
EUROAPI covers the full range of development activities, from clinical phase up to submission and launch, including regulatory support and commercial supply.
The Frankfurt site is a pioneer in solid-phase synthesis and is regularly inspected by the FDA as well as by other international and European agencies.
On November 21, 2023, EUROAPI acquired BianoGMP (“Biano”), further differentiating its value proposition to support a broader client base across the whole oligonucleotide development continuum.
More information about Biano’s exclusive small-scale cGMP oligonucleotide offering
Find out more about our CDMO services and state-of-the-art equipment for Peptides and Oligonucleotides projects:
EUROAPI Tides platform
For more information about our services
Over 15 years of expertise in oligonucleotide development
Oligonucleotides: from lab to cGMP production
EUROAPI can provide full development from OP10 to OP100-Synthesizer using semi-automated acetonitrile supply to allow production from mg to g.
3 Oligo Pilot 100 plus-Synthesizers
In a cGMP-qualified environment, the Oligo Pilot 400-Synthesizer
- Can operate with 11 different monomers
- FineLine70 (15 mmol) and 100 (30mmol)
- UNICORN process control system
State-of-the-art workshop with Oligo Process Synthesizer (cGMP)
- 200, 400 and 600 mm columns
- Vessels for reagents: 100 to 2500L
- Vessels for amidites: 5, 10, 25L
- UNICORN process control system
- Can operate with 12 different monomers
PPSM module for column packaging, cleavage from resin and deprotection
Over 45 years of expertise in peptide development
Peptides: from lab to cGMP production
EUROAPI can provide a full development pipeline for peptide synthesis with semi-automated solvent supply and waste management, thanks to its industrial location at the Hoechst Park. The Lab equipment includes:
- cGMP production
- cGMP production DSP capabilities
- 2 CS Bio 136 synthesizers
- 5 CS Bio 536 synthesizers
- 2 CS Bio 536 (0,25L – 2L)
- CS Pep process control system
CS Bio 936 / cGMP-Synthesizer with fully automated solvent supply from tank farm
- Reactor volume of 10L - 80L
- CS Pep process control system
Resin Cleavage
- Resin cleavage and precipitation in 600L vessels
- Handling of hazardous and noxious chemicals
cGMP production capabilities
Manufacturing capacities for oligonucleotides and peptides
Two Novasep(TM) cGMP chromatography units:
- Novasep(TM): 3 - 8L/min
- Columns: 110, 200, 300 and 450 mm i.D. HPLC (80-100bar); 140, 200 and 350 mm i.D. column (3-10 bar)
- TFF unit: up to 2 x 2.5 m2 filter
- Rota: 20L and 50L flask, fully automated
- Freeze dryers: 10 kg + 40 kg
- Controlled areas: up to class C, integrated freeze dryer and fraction collection area for prep-HPLC
- Barrier unit for handling potent APIs
Capacity for cool storage (e.g., product solutions).
